NCIS has experienced the departure of several key cast members, including Jennifer Esposito, Lauren Holly, Miguel Ferrer, Michael Weatherly, Pauley Perrette, Zoe McLellan, Cote de Pablo, and Mark Harmon. These exits were prompted by a variety of reasons, ranging from creative decisions to health issues and personal conflicts.
The departure of these actors has left a significant impact on the show, with some exits surprising and disappointing fans. Each actor had their unique circumstances surrounding their departure, adding to the challenges faced by the series over the years.