NCIS experienced the departure of several pivotal cast members, including Jennifer Esposito, Lauren Holly, Miguel Ferrer, Michael Weatherly, Pauley Perrette, Zoe McLellan, Cote de Pablo, and Mark Harmon. The reasons for their exits varied, encompassing creative decisions, health concerns, and personal conflicts.

These departures left a notable impact on the show, eliciting shock and disappointment from fans. Each actor had their distinct circumstances that led to their departure, adding to the challenges faced by the series throughout its run.

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